1. On Schekman’s pledge to not publish high-profile. I almost called this a balanced view, but then realized that I probably used that phrase to refer to Derek Lowe’s work at least twice in the past. The man is smart and balanced, what can I say?
2. An interesting meeting report (closed access, sorry). Two highlights:
While discussing mutations that predispose to cancer, Nazneen Rahman (Institute of Cancer Research, UK) rightly reminded us that people make big decisions and have parts of their anatomy removed based on their genotype.
Jeanne Lawrence (University of Massachusetts Medical School, USA) convincingly showed that her lab was able to silence one entire copy of chromosome 21 in stem cells in vitro. Trisomy 21 or Down’s syndrome is caused by an extra copy of chromosome 21. […] Lawrence and colleagues inserted XIST (human X-inactivation gene) into chromosome 21 in stem cells with trisomy 21. They then showed using eight different methods that a single copy of the chromosome had indeed been silenced.
|||Actually, I think it’s the only one who can be consistently trusted, but I enjoy anything by Ed Yong wherever he publishes and been reading some excellent articles by Carl Zimmer in The Atlantic.|