Metagenomic insights into the human gut resistome and the forces that shape it by Kristoffer Forslund, Shinichi Sunagawa, Luis P. Coelho, Peer Bork in Bioessays (2014) DOI:10.1002/bies.201300143
“Everyone knows” that feeding antibiotics to food animals are putting us on a path to the resistant bacterial apocalypse. However, published studies on the matter are less clear, with some authors arguing it is and others defending current use practices. So far progress in finding a definite answer has been limited due to experimental methods being expensive and cumbersome. Metagenomics offers new possibilities for understanding the evolution of antibiotic resistance and its causes, and in this review we both summarize the fledgling subfield, and present some new results of our own describing the distribution of antibiotics resistance genes in human gut microbial genomes, which we find reflects both medical and food production antibiotic use.